Phyre2 is a web-based protein modeling, prediction, and analysis server developed by the Imperial College London. It is a free and open-source resource that is widely used by scientists around the world. Phyre2 is known for its accuracy and speed, and it is able to model a wide range of proteins, including those that are difficult to model using other methods.
Phyre2 uses a variety of techniques to predict protein structure and function. The primary method is homology modeling, which involves comparing the protein sequence to a database of known protein structures.
If a similar structure is found, Phyre2 can use it to build a model of the new protein. If a similar structure is not found, Phyre2 can use other methods, such as ab initio modeling, to predict the protein structure.
In addition to predicting protein structure, Phyre2 can also predict protein function. Phyre2 does this by looking for similarities between the protein sequence and the sequences of proteins with known functions.
If a similar sequence is found, Phyre2 can infer that the new protein has a similar function. Phyre2 can also predict protein function by looking for the presence of certain functional motifs in the protein sequence.
Phyre2 is a valuable tool for scientists working in a variety of fields, including structural biology, molecular biology, and biochemistry. It is used by researchers to study protein structure and function, to design new drugs, and to develop new diagnostic methods.